About MoviPrep

MoviPrep: a low-volume colonoscopy prep

The importance of a clean colon

Colonoscopy is a potentially lifesaving procedure, but it requires an effective preparation to thoroughly cleanse your colon and rectum. That's because your doctor needs a clear view to detect and remove abnormal growths that may otherwise grow into cancer. Without an effective colonoscopy prep, your doctor may not spot potentially cancerous growths (colon polyps).

MoviPrep—prescribed nearly 8 million times in the United States since 2006

MoviPrep is a low-volume polyethylene glycol (PEG) osmotic colonoscopy preparation that is proven to effectively cleanse your colon. It was designed to provide you with a tolerable colonoscopy prep experience. MoviPrep is just as effective as 4-liter PEGs, but MoviPrep only requires you to drink 2 liters of PEG and 1 additional liter of the clear liquid of your choice. Plus, in clinical trials, it was shown that people may experience fewer gastrointestinal side effects with MoviPrep than with 4-liter colonoscopy preparations.

Table 1: The Most Common Drug-Related Adverse Reactions (≥ 2%) in the Study of MoviPrep vs. 4 Liter Polyethylene Glycol plus Electrolytes Solution

(split dose)
4L PEG + E
  n (% = n/N) n (% = n/N)
Feeling of discomfort or uneasiness 35 (19.4) 32 (17.9)
Feeling sick to your stomach 26 (14.4) 36 (20.1)
Stomach pain 24 (13.3) 27 (15.1)
Vomiting 14 (7.8) 23 (12.8)
Upper stomach pain 10 (5.6) 11 (6.1)
Indigestion 5 (2.8) 2 (1.1)

Nine out of 10 patients would take MoviPrep again for their next procedure.

Talk to your doctor about using MoviPrep for your colonoscopy preparation

If you are interested in a tolerable colonoscopy prep with less volume than traditional 4-liter bowel preps, talk to your doctor about MoviPrep.

Indication for MOVIPREP

MOVIPREP® (PEG-3350, sodium sulfate, sodium chloride, potassium chloride, sodium ascorbate and ascorbic acid for oral solution) is an osmotic laxative indicated for cleansing of the colon as a preparation for colonoscopy in adults 18 years of age or older.

Important Safety Information about MOVIPREP

  • Do not take MOVIPREP® (PEG-3350, sodium sulfate, sodium chloride, potassium chloride, sodium ascorbate and ascorbic acid for oral solution) if you have a gastrointestinal (GI) obstruction (a blockage in your bowel), bowel perforation (an opening in the wall of your stomach or intestine), gastric retention (problems with food and fluid emptying from your stomach), ileus (bowel muscle unable to move stomach contents), toxic colitis (damage to the thickness of the intestinal wall) or toxic megacolon (an extremely dilated or distended colon with fever and/or abdominal pain at times), or if you have a known allergy to MOVIPREP or any of its components.
  • It is important to drink sufficient liquids before, during, and after the use of MOVIPREP. Liquid and blood salt changes can lead to serious side effects including abnormal heartbeats, seizures, and kidney problems. Talk to your doctor before taking MOVIPREP if you take any medications that increase the risk of blood salt abnormalities or if you have known or suspected low blood salt (sodium) level (hyponatremia).
  • If you have kidney problems or if you take medication that affects kidney function, talk to your doctor before taking MOVIPREP.
  • If you have suspected bowel blockage or a suspected opening in the wall of your stomach or intestine, talk to your doctor before taking MOVIPREP.
  • Talk to your doctor before taking MOVIPREP if you have problems swallowing, if you have gastric reflux, or if you are predisposed to aspiration.
  • If you have a condition that destroys red blood cells called glucose-6-phosphate dehydrogenase (G6PD) deficiency, talk to your doctor before taking MOVIPREP.
  • Please be advised that MOVIPREP contains 131 mg of phenylalanine per treatment.
  • If you are pregnant or planning to become pregnant, talk to your doctor before taking MOVIPREP.
  • In clinical studies with MOVIPREP, the most common side effects for split dosing were malaise (feeling uneasy), nausea, stomach (abdominal) pain, vomiting, and upper stomach pain. The most common side effects for evening only dosing were stomach swelling (abdominal distension), anal discomfort, thirst, nausea, stomach (abdominal) pain, sleep disorder, rigors (body shakes), hunger, malaise (feeling uneasy), vomiting, and dizziness.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch/ or call 1-800-FDA-1088.

For product information, adverse event reports, and product complaint reports, please contact:

Salix Product Information Call Center
Phone: 1-800-508-0024
Fax: 1-510-595-8183
Email: salixmc@dlss.com

Please click here for complete Prescribing Information for MOVIPREP. 

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