About Colon Cancer

Colon cancer

While the exact cause of colon cancer (also known as colorectal cancer) is unknown, we know that the majority of colon cancers develop from abnormal growths on the lining of the colon or rectum called polyps or lesions. Anyone can develop colon cancer, but people at a higher risk for colon cancer may meet 1 or more of the following criteria:

  • Age 50 or older
  • African-American race
  • Personal or family history of colon cancer or polyps
  • Inflammatory bowel disease or other gastrointestinal (GI) issues
  • Low-fiber, high-fat diet
  • Smoking
  • Sedentary lifestyle
  • Diabetes
  • Obesity
  • Heavy alcohol use
  • Radiation therapy for cancer

Colon cancer is the third most commonly diagnosed cancer and the second leading cause of cancer-related deaths in both men and women in the United States.

Abnormal polyps and lesions could become cancerous

Diagram of cancerous polyp

If polyps and lesions are left undetected, they can slowly develop into colon cancer. Early detection and removal of these polyps and lesions are essential to cancer prevention.

Are you at risk for colon cancer?

Stages of colon cancer

As with any cancer, colon cancer has stages that describe the extent of the cancer in the body. The stage of colon cancer depends on how far the cancer has grown into the walls of the intestine and beyond. Staging is based on the results of a physical exam, biopsies, and imaging tests. The stage is essential in determining the prognosis and treatment options. The earlier cancer is diagnosed, staged, and treated, the better the prospects for survival.

Stage Characteristics
0 Cancer has yet to grow beyond the inner lining of the colon.
I-II Cancer is larger than stage 0 and has grown more deeply into, or possibly all the way through, the colon. Survival is very likely (91% for stage I, and 80% for stage II).
III Cancer has spread to lymph nodes. Survival rate is 65%.
IV Cancer has spread to other organs and is generally incurable, with a survival rate of 10%.

Can colon cancer be prevented?

Because colon cancer develops in the digestive tract, diet and colon cancer may be related. In addition to regular screening exams to detect colorectal cancer, you can make some simple lifestyle and diet changes to reduce your risk.

  • Add more vegetables, fruits, and whole grains to your diet
  • Eat less red meat
  • Reduce fat, increase fiber
  • Stop smoking
  • Reduce or eliminate your alcohol intake
  • Aim for some moderate physical activity every day
  • Maintain a healthy weight

Indication for MOVIPREP

MOVIPREP® (PEG-3350, sodium sulfate, sodium chloride, potassium chloride, sodium ascorbate and ascorbic acid for oral solution) is an osmotic laxative indicated for cleansing of the colon as a preparation for colonoscopy in adults 18 years of age or older.

Important Safety Information about MOVIPREP

Do not take MOVIPREP® (PEG-3350, sodium sulfate, sodium chloride, potassium chloride, sodium ascorbate and ascorbic acid for oral solution) if you have a gastrointestinal (GI) obstruction (a blockage in your bowel), bowel perforation (an opening in the wall of your stomach or intestine), gastric retention (problems with food and fluid emptying from your stomach), ileus (bowel muscle unable to move stomach contents), toxic colitis (damage to the thickness of the intestinal wall) or toxic megacolon (an extremely dilated or distended colon with fever and/or abdominal pain at times), or if you have a known allergy to MOVIPREP or any of its components.

It is important to drink sufficient liquids before, during, and after the use of MOVIPREP. Liquid and blood salt changes can lead to serious side effects including abnormal heartbeats, seizures, and kidney problems. Talk to your doctor before taking MOVIPREP if you take any medications that increase the risk of blood salt abnormalities or if you have known or suspected low blood salt (sodium) level (hyponatremia).

If you have kidney problems or if you take medication that affects kidney function, talk to your doctor before taking MOVIPREP.

If you have suspected bowel blockage or a suspected opening in the wall of your stomach or intestine, talk to your doctor before taking MOVIPREP.

Talk to your doctor before taking MOVIPREP if you have problems swallowing, if you have gastric reflux, or if you are predisposed to aspiration.

If you have a condition that destroys red blood cells called glucose-6-phosphate dehydrogenase (G6PD) deficiency, talk to your doctor before taking MOVIPREP.

Please be advised that MOVIPREP contains 131 mg of phenylalanine per treatment.

If you are pregnant or planning to become pregnant, talk to your doctor before taking MOVIPREP.

In clinical studies with MOVIPREP, the most common side effects for split dosing were malaise (feeling uneasy), nausea, stomach (abdominal) pain, vomiting, and upper stomach pain. The most common side effects for evening only dosing were stomach swelling (abdominal distension), anal discomfort, thirst, nausea, stomach (abdominal) pain, sleep disorder, rigors (body shakes), hunger, malaise (feeling uneasy), vomiting, and dizziness.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch/ or call 1-800-FDA-1088.

For product information, adverse event reports, and product complaint reports, please contact:

Salix Product Information Call Center
Phone: 1-800-508-0024
Fax: 1-510-595-8183
Email: salix@medcomsol.com

Please see complete Prescribing Information for MOVIPREP. pdf icon

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